Studies on Anthelmintics. IX

Time-resolved fluorescence studies on protoporphyrin IX-apohorseradish peroxidase.

The hemin moiety of horseradish peroxidase (donor:hydrogen-peroxide oxidoreductase, EC 1.11.1.7) was removed and the apoprotein reconstituted with the fluorescent protoporphyrin IX. Steady-state and time-resolved fluorescence properties of the HRP(desFe) adduct were examined; the multifrequency phase and modulation method was utilized for lifetime and dynamic polarization studies. The emission ...

Anthelmintics – From Discovery to Resistance

The scientific meeting entitled 'Anthelmintics: From Discovery to Resistance' was held in San Francisco in February 2014. The themes of the meeting were drug discovery, modes of action and resistance. Both human and veterinary parasites were covered in the oral and poster presentations. The attendees were from both academic and industrial backgrounds. In the present article we introduce a numbe...

Studies on Haemonchus contortus. IX. The effect of Trichostrongylus axei in Merinos on natural pasture.

Four groups of 6-7-month-old Merino lambs were each dosed with 40 000 infective larvae of Trichostrongylus axei on 2 November 1976 and subsequently exposed to challenge with Haemonchus contortus on natural grazing at the University of Pretoria's Experimental Farm in the eastern suburbs of Pretoria. One of these groups and one group of controls were killed every 8 weeks from the end of December ...

Studies on Digitalis. Ix. Effects of Ouabain on the Nonfailing Human Heart.

Comparative Studies on Respiration. Ix. the Effects of Antagonistic Salts on the Respiration of Aspergillus Niger

The relation of antagonistic salts to the respiration of higher fungi has received no attention. As the problems involved are of considerable interest the writer has made a beginning in this direction by conducting a series of experiments on Aspergillus niger. I t may be of interest to compare the results with those obtained on other organisms. In experiments on sea urchin eggs Warburg I and Me...